Kisspeptin-10
Master regulator of the reproductive axis that triggers GnRH release. Most potent endogenous stimulator of LH, FSH, and gonadal hormone production. Investigated for fertility treatment.
Normal Protocol
Advanced Protocol
Also Known As
Kisspeptin, Metastin fragment, KISS1 peptide, KP-10
Mechanism of Action
Product
Half-Life
Very short: approximately 4 minutes IV, 27 minutes SC
Administration Routes
Dosing Protocols
Key Research Findings
Kisspeptin-10 is the minimal active fragment of kisspeptin, a neuropeptide encoded by the KISS1 gene that serves as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin neurons in the hypothalamus directly stimulate GnRH (gonadotropin-releasing hormone) neurons, making kisspeptin the primary trigger for puberty, reproductive function, and gonadal hormone production.
Mechanism of Action
Kisspeptin-10 binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus, stimulating GnRH release. This triggers a cascade: GnRH stimulates LH and FSH release from the pituitary, which in turn stimulate testosterone (in males) or estrogen/progesterone (in females) production from the gonads. Kisspeptin is the most potent known endogenous stimulator of the reproductive axis.
Clinical Research
Dhillo et al. (2005) demonstrated that kisspeptin-10 IV infusion potently stimulated LH and FSH secretion in healthy men. George et al. (2011) showed kisspeptin-10 restored pulsatile GnRH/LH secretion in women with hypothalamic amenorrhea. Jayasena et al. conducted multiple human studies showing kisspeptin administration enhanced reproductive hormone levels and is being investigated as an alternative to GnRH analogs in assisted reproduction.
Side Effects & Warnings
Legal Status
Molecular Weight
1302.44 g/mol
Amino Acid Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Class
Research Status
Clinical TrialsHalf-Life
Very short: approximately 4 minutes IV, 27 minutes SC
Routes
Category
Performance & Body Composition